ANTIDIARE EFFECTIVENESS OF HAIR LEAF ETHANOL EXTRACT (Nephelium lappaceum Linn.) ORIGIN IN KONAWE DISTRICT, SOUTHOUTH SULAWESI IN RATS (Rattus norvegicus) INDUCED BY CASTOR OIL

Abstract

ABSTRACT

This research aimed to investigate the antidiarrheal effectiveness of ethanol extract of rambutan leaf (Nephelium lappaceum Linn.) from Konawe Regency Southeast Province on experiment mouse (Rattus norvegicus) induced with castor oil. Rambutan leaves were extracted by maceration using 96% ethanol. This research used experiment mouse (Rattus norvegicus) as many as 15 tails that were divided into 5 treatment groups, in each group were 3 experiment mouses. Group I was given 1% Na CMC 1% (negative control), group II was given colloidal attapulgite tablets (positive control), the group's III, V and V were given rambutan leaf ethanol extract of 50 mg/kg BB, 100 mg/kg BB and 150 mg/kg BB dosages. The diarrhoea testing method used is the diarrhoea protection method by observing the onset of diarrhoea, the frequency of diarrhoea and the duration of diarrhoea. The results of this study indicated that the onset of diarrhoea in group III occurred at the 65th minute, group IV at 62,6 minutes and group V at 66,33 minutes. The frequency of diarrhoea in group III occurred 7,33 times, group IV occurred 6 times, and group V occurred 5,66 times. The duration of diarrhoea in group III was 172 minutes, group IV was 122,33 minutes and group V was 77,33 minutes. Based on the data from the research that has been done, it can be concluded that the ethanol extract of rambutan leaves (Nephelium lappaceum Linn.) from Konawe Regency Southeast Sulawesi had an antidiarrheal effect on 150 mg/kg dosage which was not significantly different from colloidal attapulgite tablets.

Keywords : Antidiarrheal; Experiment Mouse (Rattus norvegicus); Rambutan Leaf  (Nephelium lappaceum Linn.