ACUTE TOXICITY TESTING OF ETHANOL ROOT AND SEED EXTRACT OF CEMPEDAK (Artocarpus hampeden Spreng) ORIGIN IN NORTH LUWU AGAINST SHRIMP (Artemia salina Leach) LARVA USING BRINE SHRIMP LETHALITY TEST (BST) METHOD

Abstract

ABSTRACT

Indonesia is an archipelagic country that has a lot of ecosystem diversity. The development of an increasingly advanced era not only provides progress in the field of technology but also in the fields of science and health. This study aims to determine the effect of acute toxicity of the ethanolic extract of the roots and seeds of cempedak (Artocarpus Champeden Spreng) typical of northern Luwu with the same concentration on larvae. shrimp (Artemia Salina Leach). The method used is the Brine Shrimp lethality Test (BST) and determines the LC 50 value of Artemia salina Leach larvae after administration of ethanol extract of cempedak roots and seeds. The results showed that the ethanol extract of cempedak root produced was very toxic with an LC50 value of 2,642 g/ML at an LC50 concentration of 0-10 g/mL and the ethanol extract of cempedak seeds had a moderately toxic effect with an LC50 value of 117.76 g/ mL at an LC50 concentration of 100-1000 g/ML. The conclusions in this study are preliminary data for further research, so it is hoped that there will be further research with the same design but different populations and research subjects in adequate numbers and for a longer study. So it is considered sufficient to see the acute effectiveness of cempedak roots and seeds for cancer viruses and can be processed in a modern way as herbal medicine.