ANTIPYRETIC EFFECTIVENES TEST OF KUNDUR FRUIT JUICE (Benincasa hispida (Thunb). Cogn) ON MALE MICE (Mus musculus)

Abstract

ABSTRACT

Fever is a symptom of a health disorder in the form of a complaint and not a diagnosis. Human body temperature is said to be fever (pyrexia) if the body temperature is more than 37.5°C. Fever can be treated with antipyretic drugs. However, some antipyretic drugs such as paracetamol can cause side effects. One alternative to reduce fever that is often used by the people of Luwu and North Luwu is Kundur Fruit Extract (Benincasa hispida). This study aims to determine whether the juice of kundur (Benincasa hispida) has an antipyretic effect in mice induced by 40% w/v baker's yeast. This research was conducted experimentally, with concentrations of kundur 75% w/v, 100% w/v, and 150% w/v grated to extract the juice. The antipyretic effectiveness test of kundur fruit juice was carried out using experimental mice (Mus musculus). From the data from the research conducted, statistical analysis of Anova showed that the calculated F value was greater than the significant value (17.694 > 0.00) so that it could be concluded that the concentration of kundur fruit juice at 75%, 100% and 150% concentrations had antipyretic effects. Kundur fruit juice with a concentration of 150% had an antipyretic effect that was not much different from paracetamol suspension in reducing body temperature of mice.